Contribution of Large Pig for Renal Ischemia-Reperfusion and Transplantation Studies: The Preclinical Model

S. Giraud (1, 2, 3, 4, 5) , Florence Favreau (6, 7, 3, 4, 5) , N. Chatauret (1, 2, 3, 4) , R. Thuillier (1, 2, 3, 4, 5) , S. Maiga (3, 5, 4) , T. Hauet (1, 2, 3, 4, 5)

1 IBISA
2 Federat Etud Ischem Reperfus Transplantat
3 UP - Université de Poitiers = University of Poitiers
4 [Poitiers] - Ischémie-Reperfusion en transplatation rénale [U 927]
5 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
6 IBISA - Groupement Scientifique - Ibisa
7 FLIRT - Fédération pour l'étude de l'ischémie reperfusion en transplantation

Animal experimentation is necessary to characterize human diseases and design adequate therapeutic interventions. In renal transplantation research, the limited number of in vitro models involves a crucial role for in vivo models and particularly for the porcine model. Pig and human kidneys are anatomically similar (characterized by multilobular structure in contrast to rodent and dog kidneys unilobular). The human proximity of porcine physiology and immune systems provides a basic knowledge of graft recovery and inflammatory physiopathology through in vivo studies. In addition, pig large body size allows surgical procedures similar to humans, repeated collections of peripheral blood or renal biopsies making pigs ideal for medical training and for the assessment of preclinical technologies. However, its size is also its main drawback implying expensive housing. Nevertheless, pig models are relevant alternatives to primate models, offering promising perspectives with developments of transgenic modulation and marginal donor models facilitating data extrapolation to human conditions.

Mots clés: LARGE ANIMAL-MODELS; SWINE CD WORKSHOP; LEUKOCYTE DIFFERENTIATION ANTIGENS; HETEROTOPIC HEART-TRANSPLANTATION; MAGNETIC-RESONANCE-SPECTROSCOPY; 3RD INTERNATIONAL WORKSHOP; CORNEAL ENDOTHELIAL-CELLS; DECAY-ACCELERATING FACTOR; PROTEIN-KINASE INHIBITOR; KIDNEY COLLECTING SYSTEM

Domaines: Sciences du Vivant [q-bio]

S. Giraud, Florence Favreau, N. Chatauret, R. Thuillier, S. Maiga, et al.. Contribution of Large Pig for Renal Ischemia-Reperfusion and Transplantation Studies: The Preclinical Model. Journal of Biomedicine and Biotechnology, 2011, pp.1-14. ⟨10.1155/2011/532127⟩. ⟨hal-02650499⟩